In a historic breakthrough, researchers at Colossal Biosciences have created genetically engineered canines resembling the extinct dire wolf, which disappeared over 10,000 years ago. Using ancient DNA, scientists modified gray wolf cells to express key dire wolf traits, leading to the birth of three pups—Romulus, Remus, and Khaleesi. While not true dire wolves, these animals represent a major step in de-extinction science, sparking ethical and ecological debates.