Leqvio (inclisiran) is a small interfering RNA (siRNA) that targets PCSK9 mRNA to lower cholesterol levels in the blood. It is prescribed for adults with primary hypercholesterolemia or mixed dyslipidemia, conditions characterized by high levels of fats, including cholesterol. A low-fat diet should be followed while taking Leqvio. It is used alongside a statin when the maximum dose of the statin is insufficient to lower cholesterol levels. It can also be combined with other cholesterol-lowering medications for individuals who cannot take statins.